Unraveling mysteries,
Unlocking therapies In the Williams lab we study the mechanisms that underlie phenotypic changes in development, so we can find new targets for human diseases. Our research uses a variety of models including induced pluripotent stem cells (iPSC) and zebrafish. Our core techniques are genetic, molecular biology, chemical biology, imaging and computational.
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RESEARCH AREAS
pH as a signaling mechanismExtracellular pH in disease is a critical determinant of pathophyciological processes, influencing tumor progression, immune response and metabolic dysregulation. While significant strides ahve been made key questions remain. Understanding the dynamics of pH alterations in diverse microenvironments, deciphering molecular mechanisms of pathology driven pH changes, and developing novel and precise modulators of these processes could pave the way for targeted and personalized interventions and therapies.
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FerroptosisFerroptosis, a regulated form of cell death, triggered by iron-dependent lipid peroxidation, has garnered attention for its role in various diseases. Despite recent advancements, several mysteries remain. Elucidating the precise regulatory mechanisms, discerning the interplay between molecular systems, and understanding the impact of environmental factors are key unresolved puzzles. Unraveling these complexities holds the potential to revolutionize therapeutic interventions and disease management.
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Cardiomyocyte BiologyUsing a iPSC (induced pluripotent stem cell) derived cardiomyocytes, gene editing, and patient driven genetic information we are trying to understand how cardiomyocytes undergo the process of cardiac maturation. How can we leverage this information to treat infantile dilated cardiomyopathy? How can we reactivate the proliferative abilities of mature cardiomyocytes? Can we improve cardiomyocyte contractile force generation without affecting calcium handling, which can cause arrhythmogenic events?
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The 4 Pillars of the Williams Lab Culture
1. Discovery
Discovery forms the bedrock of innovation and progress. Encouraging an environmnet that values curiosity and openmindedness can foster a culture of exploration and break throughs. Regular brainstorming sessions, collaborative projects, and dedicated time for independent research fuels the spirit of discovery in the laboratory.
2. Education
Education serves as the corner stone for growth and development. Prioritizing continuous learning through seminars, workshops, and mentorship programs not only enhances the knowledgebase of the team but also nurtures a culture of sharing insights and expertise. Emphasizing the importance of knowledge exchange and providing resources for skill development strengthens the educational ethos of the laboratory
3. Rigor
Rigor is the essence of maintaining high standards and precision in research. Upholding meticulous methodology, stringent controls, and a commitment to intellectual integrity are vital in ensuring credibility of the scientific endeavor, and deconstructing biases. Regular peer review of work in lab meeting, and adherence to ethical guidelines contribute to embedding rigor within the laboratory's research practices.
4. Fun
Fun adds vitality and fosters a positive work environment. We participate in social events, celebrate milestones, and achievements (academic and personal) to promote a healthy work-life balance. "If science were easy, everyone would do it", is a mantra of the lab. This field is full of ups and downs, rejections and failures. Fun keeps us all going even when it gets tough. My hope is that YOU have fun in the lab, learn, and grow and that the fruit of your work is a research product.
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PI: Charles "Chuck" Williams, PhDHi! This is just an informal introduction to myself. I am a neurodivergent (ADHD) bioscience researcher, father, and fan of fantasy and anime (my only hobbies). I grew up in Yokohama, a city just south of Tokyo Japan, and moved to the US for college where I attended Vanderbilt University. I have 1 biological child and 3 step children who are all grown and out of the nest. My passion is research, only in part because of the puzzles that are biological questions, but primarily because of human suffering. We know so much about so many things but there are still far too many diagnoses that are death sentences. The research of our team will be worth the years of effort if even one condition changes from a "make plans for the end" to "with treatment you should live another decade or more".
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